Yin Yang 1 as a prognostic factor

Yin yang

oxidative Medicine and celluar Longevity 227 Derived from classical Chinese philosophy and with frequent applications in Chinese medicine, " yin yang " has grown into an interesting concept that may have a number of applications. The term is usually used to depict the existence of polarizing or opposing forces in nature. Yet, the concept of " yin yang " can be much more involved, especially in ...

Yin and yang of MCP-1.

Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) is a chemokine of the C-C type which recruits circulating monocytes to sites of inflammation. Over the past several years, MCP-1 has become established as a major factor in the development of atherosclerosis through its promotion of monocyte/macrophage accumulation in atherosclerotic plaques, leading in turn to chronic inflammation,...

Acute Phase Reactants as a Prognostic Factor in Acute Stroke

Introduction: Elevated levels of CRP are present among patients at risk for further first-ever myocardial infarction and stroke. It has been shown that after ischemic stroke, increased levels of CRP are associated with unfavorable outcomes. Methods: From 120 patients admitted to the emergency unit of our hospital with the diagnosis of stroke CRP, D-dimer and ferritin level was measured and the ...

Yin-Yang 1, a new player in early heart development.

Yin Yang 1 Is a Negative Regulator of p53

Yin Yang 1 (YY1) is a transcription factor that plays an essential role in development. However, the full spectrum of YY1's functions and mechanism of action remains unclear. We find that YY1 ablation results in p53 accumulation due to a reduction of p53 ubiquitination in vivo. Conversely, YY1 overexpression stimulates p53 ubiquitination and degradation. Significantly, recombinant YY1 is suffic...